Literature Review – Leading Edge Topic Session #6


Intracranial Thrombus may help to diagnose Stroke aetiology
C. Dargazanli – V. Costalat

SLICE is not simply about pre-recorded stroke cases, but also in-depth reviews of current literature in this rapidly evolving field.
These compelling studies – presented to the audience with the same commitment to clarity and interaction as the cases themselves – further advance out understanding of treatment such as in this video when C. Dargazanli examines the possible role of cerebral, intracranial thrombi in diagnosing stroke.
We know that stroke is a highly heterogeneous disease whose individual causes remain too often unclear. Looking at this histological analysis, the research sought to elucidate the relationship between clot histology in terms of imaging studies and the aetiology of stroke itself with the goal of teasing out a possible tool for use in secondary prevention. If a clearly demonstrated relationship can be determined, is it possible that T-cells might be a tool to help screen for atherothrombotic etiologies? Could a high proportion of CD3+ cells in thrombi be a “reliable biomarker for stroke of atherothrombotic origin”? If further studies corroborate these findings, could this be part of an effective secondary prevention strategy? Join in the discussion with V. Costalat as we learn more about this fascinating study…